Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia

Abstract  

Previous work suggests that the methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphism A1298C may be a risk factor for schizophrenia. In this study, the genetic association between the
MTHFR A1298C polymorphism and schizophrenia was investigated in 379 patients with schizophrenia and 380 age- and sex-matched controls
subjects. The results showed an association between the 1298C allele and the disorder (OR 1.39, 95% confidence interval 1.08–1.79).
This provides further evidence that the MTHFR A1298C polymorphism may play a role in conferring risk for schizophrenia in the Chinese Han population.

• Content Type Journal Article
• DOI 10.1007/s00702-010-0442-3
• Authors
  • Chen Zhang, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wan Ping Nan Road, 200030 Shanghai, People's Republic of China
  • Bin Xie, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wan Ping Nan Road, 200030 Shanghai, People's Republic of China
  • Yasong Du, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wan Ping Nan Road, 200030 Shanghai, People's Republic of China
  • Wenhong Cheng, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wan Ping Nan Road, 200030 Shanghai, People's Republic of China
  • Yiru Fang, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wan Ping Nan Road, 200030 Shanghai, People's Republic of China
  • Shunying Yu, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wan Ping Nan Road, 200030 Shanghai, People's Republic of China

• Journal Journal of Neural Transmission
• Online ISSN 1435-1463
• Print ISSN 0300-9564